Polymyxin B Immobilized Fiber Hemoperfusion in Refractory Intra-abdominal Septic Shock
نویسندگان
چکیده
منابع مشابه
Polymyxin B-immobilized fiber column hemoperfusion therapy for septic shock.
Endotoxin, an outer membrane component of gram-negative bacteria, plays an important role in the pathogenesis of septic shock. Endotoxin adsorption therapy by polymyxin B-immobilized fiber column hemoperfusion (PMX) has been used for the treatment of septic shock patients in Japan since 1994. The covalent binding of polymyxin B onto the surface of the polystyrene-based carrier fiber in PMX inac...
متن کاملDirect hemoperfusion using polymyxin-B immobilized fiber for septic shock after cardiac surgery.
BACKGROUND The factors contributing to the efficacy and outcome of direct hemoperfusion using polymyxin-B immobilized fiber (PMX-DHP) after cardiac surgery were investigated. METHODS AND RESULTS In 23 patients who received PMX-DHP for shock related to infection after cardiac surgery, there were no differences in the pre- and intraoperative clinical data of survivors (n=14) and non-survivors (...
متن کاملPolymyxin B Hemoperfusion for Septic Shock -- Ready for Primetime? Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock: The EUPHAS Randomized Controlled Trial
Background: Treatments for severe sepsis are limited, and its morbidity and mortality, especially from Gramnegative organisms, continues to be significant. Gram-negative organisms release endotoxin, which initiates inflammatory and coagulation cascades, resulting in end-organ dysfunction in patients. Polymyxin B hemoperfusion filters bind endotoxin. Objective: To assess the efficacy of polymyxi...
متن کاملPolymyxin B-immobilized fiber column hemoperfusion mainly helps to constrict peripheral blood vessels in treatment for septic shock
BACKGROUND Polymyxin B-immobilized fiber column hemoperfusion (PMX) has been reported to be effective for patients with septic shock. It remains unclear, however, how the efficacy of PMX varies according to the characteristics and underlying conditions of the patients treated. The objective of the present study was to clarify the factors that result in clinical efficacy of PMX treatment. METH...
متن کاملAngiopoietin Balance in Septic Shock Patients With Acute Kidney Injury: Effects of Direct Hemoperfusion With Polymyxin B-Immobilized Fiber.
Acute kidney injury (AKI) occurs in approximately 50% of patients in septic shock, and mortality from septic AKI is extremely high. Angiopoietin levels may play a role in the pathogenesis of vascular permeability. It was reported that direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX) therapy ameliorates the angiopoietin balance in patients with sepsis. Although dysregul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Korean Journal of Critical Care Medicine
سال: 2015
ISSN: 2383-4870,2383-4889
DOI: 10.4266/kjccm.2015.30.2.95